ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.
Identifieur interne : 000D76 ( Main/Exploration ); précédent : 000D75; suivant : 000D77ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.
Auteurs : Cécile Thirant [France] ; Cathy Ignacimouttou [France] ; Cécile K. Lopez [France] ; M'Boyba Diop [France] ; Lou Le Mouël [France] ; Clarisse Thiollier [France] ; Aurélie Siret [France] ; Phillipe Dessen [France] ; Zakia Aid [France] ; Julie Rivière [France] ; Philippe Rameau [France] ; Céline Lefebvre [France] ; Mehdi Khaled [France] ; Guy Leverger [France] ; Paola Ballerini [France] ; Arnaud Petit [France] ; Hana Raslova [France] ; Catherine L. Carmichael [Australie] ; Benjamin T. Kile [Australie] ; Eric Soler [France] ; John D. Crispino [États-Unis] ; Christian Wichmann [Allemagne] ; Françoise Pflumio [France] ; Jürg Schwaller [Suisse] ; William Vainchenker [France] ; Camille Lobry [France] ; Nathalie Droin [France] ; Olivier A. Bernard [France] ; Sébastien Malinge [France] ; Thomas Mercher [France]Source :
- Cancer cell [ 1878-3686 ] ; 2017.
Descripteurs français
- KwdFr :
- Activation de la transcription, Animaux, Différenciation cellulaire, Enfant, Facteur de transcription GATA-1 (génétique), Humains, Leucémie aigüe mégacaryoblastique (anatomopathologie), Protéines de fusion oncogènes (), Protéines de fusion oncogènes (physiologie), Régulateur transcriptionnel ERG (physiologie), Souris, Éléments activateurs (génétique).
- MESH :
- anatomopathologie : Leucémie aigüe mégacaryoblastique.
- génétique : Facteur de transcription GATA-1.
- physiologie : Protéines de fusion oncogènes, Régulateur transcriptionnel ERG.
- Activation de la transcription, Animaux, Différenciation cellulaire, Enfant, Humains, Protéines de fusion oncogènes, Souris, Éléments activateurs (génétique).
English descriptors
- KwdEn :
- Animals, Cell Differentiation, Child, Enhancer Elements, Genetic, GATA1 Transcription Factor (genetics), Humans, Leukemia, Megakaryoblastic, Acute (pathology), Mice, Oncogene Proteins, Fusion (chemistry), Oncogene Proteins, Fusion (physiology), Transcriptional Activation, Transcriptional Regulator ERG (physiology).
- MESH :
- chemical , chemistry : Oncogene Proteins, Fusion.
- chemical , genetics : GATA1 Transcription Factor.
- pathology : Leukemia, Megakaryoblastic, Acute.
- chemical , physiology : Oncogene Proteins, Fusion, Transcriptional Regulator ERG.
- Animals, Cell Differentiation, Child, Enhancer Elements, Genetic, Humans, Mice, Transcriptional Activation.
Abstract
Chimeric transcription factors are a hallmark of human leukemia, but the molecular mechanisms by which they block differentiation and promote aberrant self-renewal remain unclear. Here, we demonstrate that the ETO2-GLIS2 fusion oncoprotein, which is found in aggressive acute megakaryoblastic leukemia, confers megakaryocytic identity via the GLIS2 moiety while both ETO2 and GLIS2 domains are required to drive increased self-renewal properties. ETO2-GLIS2 directly binds DNA to control transcription of associated genes by upregulation of expression and interaction with the ETS-related ERG protein at enhancer elements. Importantly, specific interference with ETO2-GLIS2 oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia.
DOI: 10.1016/j.ccell.2017.02.006
PubMed: 28292442
Affiliations:
- Allemagne, Australie, France, Suisse, États-Unis
- Bavière, District de Haute-Bavière, Illinois, Île-de-France
- Munich, Orsay, Paris, Villejuif
- Université Paris-Sud
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Le document en format XML
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Université Paris-Sud, 91405 Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay</wicri:regionArea><wicri:noRegion>91405 Orsay</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Thiollier, Clarisse" sort="Thiollier, Clarisse" uniqKey="Thiollier C" first="Clarisse" last="Thiollier">Clarisse Thiollier</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy, 94800 Villejuif, France; Université Paris Diderot, 75013 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, 94800 Villejuif, France; Université Paris Diderot, 75013 Paris</wicri:regionArea><wicri:noRegion>75013 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Siret, Aurelie" sort="Siret, Aurelie" uniqKey="Siret A" first="Aurélie" last="Siret">Aurélie Siret</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Dessen, Phillipe" sort="Dessen, Phillipe" uniqKey="Dessen P" first="Phillipe" last="Dessen">Phillipe Dessen</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Aid, Zakia" sort="Aid, Zakia" uniqKey="Aid Z" first="Zakia" last="Aid">Zakia Aid</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Riviere, Julie" sort="Riviere, Julie" uniqKey="Riviere J" first="Julie" last="Rivière">Julie Rivière</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Rameau, Philippe" sort="Rameau, Philippe" uniqKey="Rameau P" first="Philippe" last="Rameau">Philippe Rameau</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Lefebvre, Celine" sort="Lefebvre, Celine" uniqKey="Lefebvre C" first="Céline" last="Lefebvre">Céline Lefebvre</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Khaled, Mehdi" sort="Khaled, Mehdi" uniqKey="Khaled M" first="Mehdi" last="Khaled">Mehdi Khaled</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Leverger, Guy" sort="Leverger, Guy" uniqKey="Leverger G" first="Guy" last="Leverger">Guy Leverger</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Trousseau, AP-HP, 75012 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Trousseau, AP-HP, 75012 Paris</wicri:regionArea><wicri:noRegion>75012 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Ballerini, Paola" sort="Ballerini, Paola" uniqKey="Ballerini P" first="Paola" last="Ballerini">Paola Ballerini</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Trousseau, AP-HP, 75012 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Trousseau, AP-HP, 75012 Paris</wicri:regionArea><wicri:noRegion>75012 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Petit, Arnaud" sort="Petit, Arnaud" uniqKey="Petit A" first="Arnaud" last="Petit">Arnaud Petit</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Trousseau, AP-HP, 75012 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Trousseau, AP-HP, 75012 Paris</wicri:regionArea><wicri:noRegion>75012 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Raslova, Hana" sort="Raslova, Hana" uniqKey="Raslova H" first="Hana" last="Raslova">Hana Raslova</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Carmichael, Catherine L" sort="Carmichael, Catherine L" uniqKey="Carmichael C" first="Catherine L" last="Carmichael">Catherine L. Carmichael</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Kile, Benjamin T" sort="Kile, Benjamin T" uniqKey="Kile B" first="Benjamin T" last="Kile">Benjamin T. Kile</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Soler, Eric" sort="Soler, Eric" uniqKey="Soler E" first="Eric" last="Soler">Eric Soler</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR967, 92265 Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR967, 92265 Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>92265 Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>92265 Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Crispino, John D" sort="Crispino, John D" uniqKey="Crispino J" first="John D" last="Crispino">John D. Crispino</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Wichmann, Christian" sort="Wichmann, Christian" uniqKey="Wichmann C" first="Christian" last="Wichmann">Christian Wichmann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilian University Hospital, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilian University Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Pflumio, Francoise" sort="Pflumio, Francoise" uniqKey="Pflumio F" first="Françoise" last="Pflumio">Françoise Pflumio</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR967, 92265 Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR967, 92265 Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>92265 Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>92265 Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Schwaller, Jurg" sort="Schwaller, Jurg" uniqKey="Schwaller J" first="Jürg" last="Schwaller">Jürg Schwaller</name><affiliation wicri:level="1"><nlm:affiliation>University Children's Hospital Beider Basel (UKBB), Departement of Biomedicine, University of Basel, 4031 Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Children's Hospital Beider Basel (UKBB), Departement of Biomedicine, University of Basel, 4031 Basel</wicri:regionArea><wicri:noRegion>4031 Basel</wicri:noRegion></affiliation></author><author><name sortKey="Vainchenker, William" sort="Vainchenker, William" uniqKey="Vainchenker W" first="William" last="Vainchenker">William Vainchenker</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Lobry, Camille" sort="Lobry, Camille" uniqKey="Lobry C" first="Camille" last="Lobry">Camille Lobry</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Droin, Nathalie" sort="Droin, Nathalie" uniqKey="Droin N" first="Nathalie" last="Droin">Nathalie Droin</name><affiliation wicri:level="4"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay, France; INSERM U523, CNRS UMS3655, Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay, France; INSERM U523, CNRS UMS3655, Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bernard, Olivier A" sort="Bernard, Olivier A" uniqKey="Bernard O" first="Olivier A" last="Bernard">Olivier A. Bernard</name><affiliation wicri:level="4"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay</wicri:regionArea><wicri:noRegion>91405 Orsay</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Malinge, Sebastien" sort="Malinge, Sebastien" uniqKey="Malinge S" first="Sébastien" last="Malinge">Sébastien Malinge</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Mercher, Thomas" sort="Mercher, Thomas" uniqKey="Mercher T" first="Thomas" last="Mercher">Thomas Mercher</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris Diderot, 75013 Paris, France; Université Paris-Sud, 91405 Orsay, France. Electronic address: thomas.mercher@inserm.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris Diderot, 75013 Paris, France; Université Paris-Sud, 91405 Orsay</wicri:regionArea><wicri:noRegion>91405 Orsay</wicri:noRegion><wicri:noRegion>91405 Orsay</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28292442</idno><idno type="pmid">28292442</idno><idno type="doi">10.1016/j.ccell.2017.02.006</idno><idno type="wicri:Area/PubMed/Corpus">001001</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001001</idno><idno type="wicri:Area/PubMed/Curation">000F98</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F98</idno><idno type="wicri:Area/PubMed/Checkpoint">000F98</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F98</idno><idno type="wicri:Area/Ncbi/Merge">004464</idno><idno type="wicri:Area/Ncbi/Curation">004464</idno><idno type="wicri:Area/Ncbi/Checkpoint">004464</idno><idno type="wicri:Area/Main/Merge">000D71</idno><idno type="wicri:Area/Main/Curation">000D76</idno><idno type="wicri:Area/Main/Exploration">000D76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.</title><author><name sortKey="Thirant, Cecile" sort="Thirant, Cecile" uniqKey="Thirant C" first="Cécile" last="Thirant">Cécile Thirant</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author><author><name sortKey="Ignacimouttou, Cathy" sort="Ignacimouttou, Cathy" uniqKey="Ignacimouttou C" first="Cathy" last="Ignacimouttou">Cathy Ignacimouttou</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Université Paris Diderot, 75013 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Université Paris Diderot, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lopez, Cecile K" sort="Lopez, Cecile K" uniqKey="Lopez C" first="Cécile K" last="Lopez">Cécile K. Lopez</name><affiliation wicri:level="4"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Orsay</settlement><settlement type="city">Orsay</settlement></placeName><orgName type="university">Université Paris-Sud</orgName></affiliation></author><author><name sortKey="Diop, M Boyba" sort="Diop, M Boyba" uniqKey="Diop M" first="M'Boyba" last="Diop">M'Boyba Diop</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Le Mouel, Lou" sort="Le Mouel, Lou" uniqKey="Le Mouel L" first="Lou" last="Le Mouël">Lou Le Mouël</name><affiliation wicri:level="4"><nlm:affiliation>Gustave Roussy, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay</wicri:regionArea><wicri:noRegion>91405 Orsay</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Thiollier, Clarisse" sort="Thiollier, Clarisse" uniqKey="Thiollier C" first="Clarisse" last="Thiollier">Clarisse Thiollier</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy, 94800 Villejuif, France; Université Paris Diderot, 75013 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, 94800 Villejuif, France; Université Paris Diderot, 75013 Paris</wicri:regionArea><wicri:noRegion>75013 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Siret, Aurelie" sort="Siret, Aurelie" uniqKey="Siret A" first="Aurélie" last="Siret">Aurélie Siret</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Dessen, Phillipe" sort="Dessen, Phillipe" uniqKey="Dessen P" first="Phillipe" last="Dessen">Phillipe Dessen</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Aid, Zakia" sort="Aid, Zakia" uniqKey="Aid Z" first="Zakia" last="Aid">Zakia Aid</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Riviere, Julie" sort="Riviere, Julie" uniqKey="Riviere J" first="Julie" last="Rivière">Julie Rivière</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Rameau, Philippe" sort="Rameau, Philippe" uniqKey="Rameau P" first="Philippe" last="Rameau">Philippe Rameau</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Lefebvre, Celine" sort="Lefebvre, Celine" uniqKey="Lefebvre C" first="Céline" last="Lefebvre">Céline Lefebvre</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Khaled, Mehdi" sort="Khaled, Mehdi" uniqKey="Khaled M" first="Mehdi" last="Khaled">Mehdi Khaled</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Leverger, Guy" sort="Leverger, Guy" uniqKey="Leverger G" first="Guy" last="Leverger">Guy Leverger</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Trousseau, AP-HP, 75012 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Trousseau, AP-HP, 75012 Paris</wicri:regionArea><wicri:noRegion>75012 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Ballerini, Paola" sort="Ballerini, Paola" uniqKey="Ballerini P" first="Paola" last="Ballerini">Paola Ballerini</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Trousseau, AP-HP, 75012 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Trousseau, AP-HP, 75012 Paris</wicri:regionArea><wicri:noRegion>75012 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Petit, Arnaud" sort="Petit, Arnaud" uniqKey="Petit A" first="Arnaud" last="Petit">Arnaud Petit</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Trousseau, AP-HP, 75012 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Trousseau, AP-HP, 75012 Paris</wicri:regionArea><wicri:noRegion>75012 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Raslova, Hana" sort="Raslova, Hana" uniqKey="Raslova H" first="Hana" last="Raslova">Hana Raslova</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Carmichael, Catherine L" sort="Carmichael, Catherine L" uniqKey="Carmichael C" first="Catherine L" last="Carmichael">Catherine L. Carmichael</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Kile, Benjamin T" sort="Kile, Benjamin T" uniqKey="Kile B" first="Benjamin T" last="Kile">Benjamin T. Kile</name><affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Soler, Eric" sort="Soler, Eric" uniqKey="Soler E" first="Eric" last="Soler">Eric Soler</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR967, 92265 Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR967, 92265 Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>92265 Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>92265 Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Crispino, John D" sort="Crispino, John D" uniqKey="Crispino J" first="John D" last="Crispino">John D. Crispino</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Wichmann, Christian" sort="Wichmann, Christian" uniqKey="Wichmann C" first="Christian" last="Wichmann">Christian Wichmann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilian University Hospital, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilian University Hospital, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Pflumio, Francoise" sort="Pflumio, Francoise" uniqKey="Pflumio F" first="Françoise" last="Pflumio">Françoise Pflumio</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR967, 92265 Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR967, 92265 Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>92265 Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>92265 Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Schwaller, Jurg" sort="Schwaller, Jurg" uniqKey="Schwaller J" first="Jürg" last="Schwaller">Jürg Schwaller</name><affiliation wicri:level="1"><nlm:affiliation>University Children's Hospital Beider Basel (UKBB), Departement of Biomedicine, University of Basel, 4031 Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University Children's Hospital Beider Basel (UKBB), Departement of Biomedicine, University of Basel, 4031 Basel</wicri:regionArea><wicri:noRegion>4031 Basel</wicri:noRegion></affiliation></author><author><name sortKey="Vainchenker, William" sort="Vainchenker, William" uniqKey="Vainchenker W" first="William" last="Vainchenker">William Vainchenker</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Lobry, Camille" sort="Lobry, Camille" uniqKey="Lobry C" first="Camille" last="Lobry">Camille Lobry</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Droin, Nathalie" sort="Droin, Nathalie" uniqKey="Droin N" first="Nathalie" last="Droin">Nathalie Droin</name><affiliation wicri:level="4"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay, France; INSERM U523, CNRS UMS3655, Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay, France; INSERM U523, CNRS UMS3655, Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bernard, Olivier A" sort="Bernard, Olivier A" uniqKey="Bernard O" first="Olivier A" last="Bernard">Olivier A. Bernard</name><affiliation wicri:level="4"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris-Sud, 91405 Orsay</wicri:regionArea><wicri:noRegion>91405 Orsay</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Malinge, Sebastien" sort="Malinge, Sebastien" uniqKey="Malinge S" first="Sébastien" last="Malinge">Sébastien Malinge</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif</wicri:regionArea><wicri:noRegion>94800 Villejuif</wicri:noRegion><wicri:noRegion>94800 Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Mercher, Thomas" sort="Mercher, Thomas" uniqKey="Mercher T" first="Thomas" last="Mercher">Thomas Mercher</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris Diderot, 75013 Paris, France; Université Paris-Sud, 91405 Orsay, France. Electronic address: thomas.mercher@inserm.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94800 Villejuif, France; Gustave Roussy, 94800 Villejuif, France; Université Paris Diderot, 75013 Paris, France; Université Paris-Sud, 91405 Orsay</wicri:regionArea><wicri:noRegion>91405 Orsay</wicri:noRegion><wicri:noRegion>91405 Orsay</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancer cell</title><idno type="eISSN">1878-3686</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Differentiation</term><term>Child</term><term>Enhancer Elements, Genetic</term><term>GATA1 Transcription Factor (genetics)</term><term>Humans</term><term>Leukemia, Megakaryoblastic, Acute (pathology)</term><term>Mice</term><term>Oncogene Proteins, Fusion (chemistry)</term><term>Oncogene Proteins, Fusion (physiology)</term><term>Transcriptional Activation</term><term>Transcriptional Regulator ERG (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation de la transcription</term><term>Animaux</term><term>Différenciation cellulaire</term><term>Enfant</term><term>Facteur de transcription GATA-1 (génétique)</term><term>Humains</term><term>Leucémie aigüe mégacaryoblastique (anatomopathologie)</term><term>Protéines de fusion oncogènes ()</term><term>Protéines de fusion oncogènes (physiologie)</term><term>Régulateur transcriptionnel ERG (physiologie)</term><term>Souris</term><term>Éléments activateurs (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Oncogene Proteins, Fusion</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>GATA1 Transcription Factor</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Leucémie aigüe mégacaryoblastique</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de transcription GATA-1</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Leukemia, Megakaryoblastic, Acute</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Protéines de fusion oncogènes</term><term>Régulateur transcriptionnel ERG</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Oncogene Proteins, Fusion</term><term>Transcriptional Regulator ERG</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Differentiation</term><term>Child</term><term>Enhancer Elements, Genetic</term><term>Humans</term><term>Mice</term><term>Transcriptional Activation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation de la transcription</term><term>Animaux</term><term>Différenciation cellulaire</term><term>Enfant</term><term>Humains</term><term>Protéines de fusion oncogènes</term><term>Souris</term><term>Éléments activateurs (génétique)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chimeric transcription factors are a hallmark of human leukemia, but the molecular mechanisms by which they block differentiation and promote aberrant self-renewal remain unclear. Here, we demonstrate that the ETO2-GLIS2 fusion oncoprotein, which is found in aggressive acute megakaryoblastic leukemia, confers megakaryocytic identity via the GLIS2 moiety while both ETO2 and GLIS2 domains are required to drive increased self-renewal properties. ETO2-GLIS2 directly binds DNA to control transcription of associated genes by upregulation of expression and interaction with the ETS-related ERG protein at enhancer elements. Importantly, specific interference with ETO2-GLIS2 oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Suisse</li><li>États-Unis</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Illinois</li><li>Île-de-France</li></region><settlement><li>Munich</li><li>Orsay</li><li>Paris</li><li>Villejuif</li></settlement><orgName><li>Université Paris-Sud</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Thirant, Cecile" sort="Thirant, Cecile" uniqKey="Thirant C" first="Cécile" last="Thirant">Cécile Thirant</name></region><name sortKey="Aid, Zakia" sort="Aid, Zakia" uniqKey="Aid Z" first="Zakia" last="Aid">Zakia Aid</name><name sortKey="Ballerini, Paola" sort="Ballerini, Paola" uniqKey="Ballerini P" first="Paola" last="Ballerini">Paola Ballerini</name><name sortKey="Bernard, Olivier A" sort="Bernard, Olivier A" uniqKey="Bernard O" first="Olivier A" last="Bernard">Olivier A. Bernard</name><name sortKey="Dessen, Phillipe" sort="Dessen, Phillipe" uniqKey="Dessen P" first="Phillipe" last="Dessen">Phillipe Dessen</name><name sortKey="Diop, M Boyba" sort="Diop, M Boyba" uniqKey="Diop M" first="M'Boyba" last="Diop">M'Boyba Diop</name><name sortKey="Droin, Nathalie" sort="Droin, Nathalie" uniqKey="Droin N" first="Nathalie" last="Droin">Nathalie Droin</name><name sortKey="Ignacimouttou, Cathy" sort="Ignacimouttou, Cathy" uniqKey="Ignacimouttou C" first="Cathy" last="Ignacimouttou">Cathy Ignacimouttou</name><name sortKey="Khaled, Mehdi" sort="Khaled, Mehdi" uniqKey="Khaled M" first="Mehdi" last="Khaled">Mehdi Khaled</name><name sortKey="Le Mouel, Lou" sort="Le Mouel, Lou" uniqKey="Le Mouel L" first="Lou" last="Le Mouël">Lou Le Mouël</name><name sortKey="Lefebvre, Celine" sort="Lefebvre, Celine" uniqKey="Lefebvre C" first="Céline" last="Lefebvre">Céline Lefebvre</name><name sortKey="Leverger, Guy" sort="Leverger, Guy" uniqKey="Leverger G" first="Guy" last="Leverger">Guy Leverger</name><name sortKey="Lobry, Camille" sort="Lobry, Camille" uniqKey="Lobry C" first="Camille" last="Lobry">Camille Lobry</name><name sortKey="Lopez, Cecile K" sort="Lopez, Cecile K" uniqKey="Lopez C" first="Cécile K" last="Lopez">Cécile K. Lopez</name><name sortKey="Malinge, Sebastien" sort="Malinge, Sebastien" uniqKey="Malinge S" first="Sébastien" last="Malinge">Sébastien Malinge</name><name sortKey="Mercher, Thomas" sort="Mercher, Thomas" uniqKey="Mercher T" first="Thomas" last="Mercher">Thomas Mercher</name><name sortKey="Petit, Arnaud" sort="Petit, Arnaud" uniqKey="Petit A" first="Arnaud" last="Petit">Arnaud Petit</name><name sortKey="Pflumio, Francoise" sort="Pflumio, Francoise" uniqKey="Pflumio F" first="Françoise" last="Pflumio">Françoise Pflumio</name><name sortKey="Rameau, Philippe" sort="Rameau, Philippe" uniqKey="Rameau P" first="Philippe" last="Rameau">Philippe Rameau</name><name sortKey="Raslova, Hana" sort="Raslova, Hana" uniqKey="Raslova H" first="Hana" last="Raslova">Hana Raslova</name><name sortKey="Riviere, Julie" sort="Riviere, Julie" uniqKey="Riviere J" first="Julie" last="Rivière">Julie Rivière</name><name sortKey="Siret, Aurelie" sort="Siret, Aurelie" uniqKey="Siret A" first="Aurélie" last="Siret">Aurélie Siret</name><name sortKey="Soler, Eric" sort="Soler, Eric" uniqKey="Soler E" first="Eric" last="Soler">Eric Soler</name><name sortKey="Thiollier, Clarisse" sort="Thiollier, Clarisse" uniqKey="Thiollier C" first="Clarisse" last="Thiollier">Clarisse Thiollier</name><name sortKey="Vainchenker, William" sort="Vainchenker, William" uniqKey="Vainchenker W" first="William" last="Vainchenker">William Vainchenker</name></country><country name="Australie"><noRegion><name sortKey="Carmichael, Catherine L" sort="Carmichael, Catherine L" uniqKey="Carmichael C" first="Catherine L" last="Carmichael">Catherine L. Carmichael</name></noRegion><name sortKey="Kile, Benjamin T" sort="Kile, Benjamin T" uniqKey="Kile B" first="Benjamin T" last="Kile">Benjamin T. Kile</name></country><country name="États-Unis"><region name="Illinois"><name sortKey="Crispino, John D" sort="Crispino, John D" uniqKey="Crispino J" first="John D" last="Crispino">John D. Crispino</name></region></country><country name="Allemagne"><region name="Bavière"><name sortKey="Wichmann, Christian" sort="Wichmann, Christian" uniqKey="Wichmann C" first="Christian" last="Wichmann">Christian Wichmann</name></region></country><country name="Suisse"><noRegion><name sortKey="Schwaller, Jurg" sort="Schwaller, Jurg" uniqKey="Schwaller J" first="Jürg" last="Schwaller">Jürg Schwaller</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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